2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-137258
    (±)-N-3-Benzylnirvanol 93879-40-4 99.88%
    (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively.
    (±)-N-3-Benzylnirvanol
  • HY-137813
    PERK-IN-4 1337531-89-1 98.30%
    PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states.
    PERK-IN-4
  • HY-139066
    Punicic acid 544-72-9 ≥98.0%
    Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways.
    Punicic acid
  • HY-143312
    V-0219 878453-71-5 98.65%
    V-0219 (Compound 9) is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). V-0219 can be used for obesity-associated diabetes research.
    V-0219
  • HY-145542
    Isovalerylcarnitine chloride 139144-12-0 ≥98.0%
    Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils.
    Isovalerylcarnitine chloride
  • HY-163316
    SIRT4-IN-1
    SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms.
    SIRT4-IN-1
  • HY-B0093A
    Benazepril hydrochloride 86541-74-4 99.96%
    Benazepril (CGS14824A) hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor to reduce angiotensin-II production. Benazepril hydrochloride inhibits oxidative stress and inhibits apoptosis by the PI3K/Akt signaling pathway. In addition, Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria. Benazepril hydrochloride can be used in the study of hypertension, heart failure and diabetic nephropathy.
    Benazepril hydrochloride
  • HY-B0135A
    Furosemide sodium 41733-55-5 99.89%
    Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
    Furosemide sodium
  • HY-N0182R
    Fisetin (Standard) 528-48-3 98.47%
    Fisetin (Standard) is the analytical standard of Fisetin. This product is intended for research and analytical applications. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
    Fisetin (Standard)
  • HY-N0390R
    L-Glutamine (standard) 56-85-9
    L-Glutamine (Standard) is the analytical standard of L-Glutamine. This product is intended for research and analytical applications. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine (standard)
  • HY-P1806A
    Gastrin I (1-14), human TFA 99.87%
    Gastrin I (1-14), human TFA is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.
    Gastrin I (1-14), human TFA
  • HY-P4146A
    Survodutide TFA 99.62%
    Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
    Survodutide TFA
  • HY-103642A
    D-myo-Inositol-1,4,5-triphosphate trisodium 141611-10-1 99.80%
    D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
    D-myo-Inositol-1,4,5-triphosphate trisodium
  • HY-112868B
    ABH hydrochloride 194656-75-2
    ABH (hydrochloride) is an orally active arginase inhibitor (Ki = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis.
    ABH hydrochloride
  • HY-118861A
    Enclomiphene citrate 7599-79-3 99.96%
    Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.
    Enclomiphene citrate
  • HY-W006371
    (2-Aminoethyl)phosphonic acid 2041-14-7 ≥98.0%
    (2-Aminoethyl)phosphonic acid is an endogenous metabolite.
    (2-Aminoethyl)phosphonic acid
  • HY-W011689
    6PPD 793-24-8 99.44%
    6PPD is a rubber antioxidant that scavenges ozone, forming nitroxyl radicals. 6PPD exposure decreases hatchability, lowered autonomous movement, reduces body length in zebrafish embryos and causes deformities. 6PPD also produces oxidative stress in zebrafish embryos.
    6PPD
  • HY-W014504
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 343-65-7 98.95%
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
  • HY-W015300
    Suberic acid 505-48-6 ≥98.0%
    Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
    Suberic acid
  • HY-W018197
    2-Phenylacetamide 103-81-1 99.92%
    2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active.
    2-Phenylacetamide
Cat. No. Product Name / Synonyms Application Reactivity